CompletedPhase 2ketamine

Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI

NCT ID

NCT04600089

Target Enrollment

21 participants

Start Date

2020-12-08

Est. Completion

2025-10-17

About This Study

The objective of this study is to identify the opioid-sparing effects, and pain-reduction potential of low dose, sub-dissociative ketamine on patients undergoing thoracic endovascular aortic repair (TEVAR) procedures receiving naloxone continuous infusion (NCI).

Conditions Studied

Descending Aortic DissectionPostoperative PainThoracoabdominal Aortic Aneurysm

Interventions

•Saline
•Ketamine

Eligibility

Age:18 Years - 90 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* willing to give informed consent
* scheduled for elective thoracic aorta repair or thoracoabdominal aortic repair
* requires naloxone continuous infusion for spinal prophylaxis

Exclusion Criteria:

* allergy to ketamine, acetaminophen, or fentanyl
* diagnosis of schizophrenia
* history of hydrocephalus or central nervous system mass
* incarcerated individuals
* pregnant or lactating individuals

Study Locations (1)

University of Kentucky Medical Center

Lexington, Kentucky, United States