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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 12971344 of 1750 trials
Recruiting·N/A·Other

Measuring Analgesic Interventions

Julia Finkel

Pain
Recruiting·N/A·ketamine

Ketamine Enhances Analgesia and Mood in Chronic Pain Patients

Salem Anaesthesia Pain Clinic

Mood Disorder; OpioidMood Insomnia
Recruiting·N/A·ketamine

Dexmedetomidine and Ketamine in VATS Surgery

Ciusss de L'Est de l'Île de Montréal

Postoperative PainOpioid Use
Recruiting·Phase 4·ketamine

ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression

University of Saskatchewan

Treatment Resistant DepressionKetamine
Recruiting·Phase 1·ketamine

Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

National Institute of Mental Health (NIMH)

Healthy VolunteerMajor Depressive DisorderDepression
Recruiting·Phase 1·psilocybin

The Neurobiological Effect of 5-HT2AR Modulation

Gitte Moos Knudsen

Basic Science
Recruiting·Phase 2·ketamine

Neurobiology of Suicide

National Institute of Mental Health (NIMH)

Healthy VolunteersDepression
Recruiting·Phase 2·ketamine

Ketamine Alcohol (in Treatment-Resistant Depression)

Mark Niciu

Magnetic Resonance ImagingMajor DepressionAlcoholism
Recruiting·N/A·Other

National Pregnancy Registry for Psychiatric Medications

Massachusetts General Hospital

Pregnant WomenPsychotropic Drugs
Suspended·Early Phase 1·psilocybin

Safety Profile of Psilocybin for Cocaine Use Disorder

University of California, Los Angeles

Cocaine Use Disorder
Suspended·Phase 2·Other

Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002

Global Coalition for Adaptive Research

Post Traumatic Stress Disorder
Suspended·Phase 2·ketamine

Ketamine HCl Prolonged Release Oral Tablets for CRPS

University of Southern California

Complex Regional Pain Syndromes
Suspended·Early Phase 1·ketamine

Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)

University of Wisconsin, Madison

Posttraumatic Stress Disorder
Suspended·Phase 1·ketamine

Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery

University of Utah

PainPostpartum Depression
Suspended·Phase 4·ketamine

Ketamine for Sedation in Severe Traumatic Brain Injury

Henry M. Jackson Foundation for the Advancement of Military Medicine

Severe Traumatic Brain InjuryIntracranial HypertensionIntracranial Hemorrhage, Hypertensive
Suspended·Phase 2·psilocybin

An Investigation of Psilocybin on Behavioural and Cognitive Symptoms of Adults With Fragile X Syndrome

Nova Mentis Life Science Corp

Fragile X SyndromeBehaviorCognitive Dysfunction
Suspended·N/A·ketamine

Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment

University of Pittsburgh

Depression
Suspended·Phase 2·ketamine

Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia

PharmaTher Inc.

DyskinesiasMovement DisordersCentral Nervous System Diseases+2 more
Suspended·Phase 4·ketamine

IM Ketamine vs Midazolam for Suicidal ER Patients

New York State Psychiatric Institute

Depression, UnipolarDepression, BipolarSuicidal Ideation
Suspended·Phase 3·ketamine

Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion

Dr. Marie Eve Sophie Bussiere-Cote

Abortion in First Trimester
Suspended·Phase 3·ketamine

Ketamine Versus Electroconvulsive Therapy in Depression

University of Ottawa

Depressive Disorder, MajorBipolar Depression
Suspended·Phase 2·ketamine

A Study of Human Multi-Sensory Integration

University of Pennsylvania

Anesthesia Awareness
Suspended·N/A·ketamine

Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy

Rabin Medical Center

Paediatric Flexible Bronchoscopy
Suspended·Phase 3·ketamine

Systemic Ketamine for the Improvement of Post-Operative Analgesia at the Alcohol-Dependent Patient

University Hospital, Clermont-Ferrand

Alcoholic PatientCarcinological Surgery ORL
Terminated·N/A·psilocybin

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

Yale University

OCDMajor Depressive Disorder (MDD)Alcohol Use Disorder (AUD)+8 more
Terminated·N/A·ketamine

Role Of Non-Specific Effects in The Treatment of Depression With Esketamine

Yale University

Depressive Episode
Terminated·Phase 2·ketamine

Ketamine for OUD and Suicidal Ideation in the ED

Brigham and Women's Hospital

Opioid Use DisorderSuicidal Ideation
Terminated·N/A·ketamine

Behavioural Activation Therapy and Esketamine for Resistant Depression

The Royal's Institute of Mental Health Research

Depressive Disorder, Treatment-ResistantDepressive Disorder, MajorBipolar Disorder
Terminated·Phase 4·ketamine

Ketamine-assisted Therapy for Advanced GI Cancer

Brian Anderson, MD

Pancreatic Ductal AdenocarcinomaPain, AcuteGastrointestinal Cancers+1 more
Terminated·Early Phase 1·ketamine

Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers

University of Utah

Gastrointestinal CancerDepressionAnxiety
Terminated·Phase 2·ketamine

Opioid-Free Pain Control Regimen Following Robotic Radical Prostatectomy

Wake Forest University Health Sciences

Pain ManagementOpioid UseProstate Cancer
Terminated·Phase 2·DMT

Phase 2 Clinical Trial of GH001 in Bipolar II Disorder

GH Research Ireland Limited

Bipolar II Disorder
Terminated·Phase 1·psilocybin

Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder

University of Wisconsin, Madison

Methamphetamine Use DisorderSubstance-Related DisordersChemically-Induced Disorders+2 more
Terminated·Phase 2·DMT

Phase 2 Clinical Trial of GH001 in Postpartum Depression

GH Research Ireland Limited

Postpartum DepressionPostnatal Depression
Terminated·Phase 1·ketamine

[11C]-(R)-Rolipram to Measure cAMP Signaling Before and After Ketamine

National Institute of Mental Health (NIMH)

Depression
Terminated·Phase 2·ketamine

Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant Depression

Zylorion Health

Treatment Resistant Major Depressive Disorder
Terminated·Phase 4·ketamine

Ketamine Pilot Study

Meghan Spyres

Rattlesnake Envenomation
Terminated·Phase 1·ketamine

Ketamine Infusion for Rapid Reduction of Suicidality in Pediatrics

University of British Columbia

Suicidal Ideation
Terminated·Phase 4·ketamine

Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the ED

University of Aarhus

Acute PainOpioid Use
Terminated·Phase 1·ketamine

The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) Study

NYU Langone Health

EndometriosisPost Operative Pain
Terminated·Phase 1·ketamine

Ketamine for OUD and Comorbid Depression (OUDCD)

University of Maryland, Baltimore

Opioid Use DisorderDepressive Disorder
Terminated·Phase 2·ketamine

Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine

Yale University

Adolescent SuicideAdolescent Depression
Terminated·Phase 2·ketamine

KAP for Depression in Abstinent Opioid Users

Medical University of South Carolina

Opioid Use Disorder, Severe, in Sustained RemissionOpioid Use Disorder, Severe, in Early RemissionMajor Depressive Disorder
Terminated·N/A·ketamine

Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG)

Entheon Biomedical Corp.

Treatment-resistant Depression
Terminated·Phase 2·MDMA

Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD

Resilient Pharmaceuticals

PTSD
Terminated·Phase 4·Other

Vital Capacity in Ultrasound Guided Serratus Plane Block in ED Patients With Multiple Rib Fractures

Antonios Likourezos

Pain
Terminated·Phase 1·psilocybin

Visual Surround Suppression and Perceptual Expectation Under Psilocybin

University of Minnesota

Perception DisturbanceVisual SuppressionPsychedelic Experiences
Terminated·Phase 1·psilocybin

Phase 1b Study in Patients With Short-Lasting Unilateral Neuralgiform Headache Attacks (SUNHA)

Beckley Psytech Limited

Short Lasting Unilateral Neuralgiform Headache Attacks
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.