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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 145–192 of 1553 trials
Completed·N/A·ketamine

Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression

Medical University of Gdansk

Treatment-Resistant DepressionMajor Depressive Disorder
Completed·Phase 1·psilocybin

Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers

University of Nebraska

Pancreas CancerBiliary Tract CancerPsychological Distress+1 more
Completed·N/A·ketamine

Effect of Ketamine Infusion on BIS Values

University of Padova

Anesthesia Brain MonitoringKetamine
Completed·N/A·ketamine

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Beth Israel Deaconess Medical Center

Postoperative DeliriumHemodynamic InstabilityPain+1 more
Completed·Early Phase 1·ayahuasca

Mindfulness and Psychedelics

Milan Scheidegger

Healthy Participants
Completed·N/A·DMT

Real-World Persistence and Adherence of Ofatumumab Compared to Self-Injectable and Oral DMTs in Patients With Multiple Sclerosis

Novartis

Multiple Sclerosis
Completed·Early Phase 1·ketamine

The Effects of Sedatives on Tobacco Use Disorder Version 2

Wake Forest University Health Sciences

Tobacco Smoking
Completed·Phase 3·psilocybin

Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD

COMPASS Pathways

Treatment Resistant Depression
Completed·N/A·DMT

The 'Wearing Off' Effect of DMT

Novartis Pharmaceuticals

Multiple Sclerosis
Completed·Phase 1·psilocybin

PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout

University of Utah

DepressionBurnout, Professional
Completed·Phase 2·psilocybin

Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder

Ohio State University

PTSDStress Disorders, TraumaticStress Disorders, Post-Traumatic+2 more
Completed·Phase 1·DMT

Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy Volunteers

Usona Institute

PharmacokineticsSafetyTolerability
Completed·Phase 1·DMT

Safety and Pharmacokinetics of GH002 in Healthy Volunteers

GH Research Ireland Limited

Healthy Volunteers
Completed·Phase 1·DMT

SPL026 With or Without SSRIs in Participants With MDD

Small Pharma Ltd

Major Depressive Disorder
Completed·N/A·psilocybin

Psilocybin in Adults With and Without Autism Spectrum Disorder

King's College London

Autism Spectrum Disorder
Completed·Phase 4·ketamine

Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects

Summa Health System

Pain, AcuteDissociation
Completed·Phase 4·ketamine

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

Theresa Jacob, PhD, MPH

Treatment Resistant DepressionMajor Depressive DisorderAnalgesia+10 more
Completed·Phase 1·DMT

Acute Dose-dependent Effects of DMT in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 4·ketamine

Comparison of Esketamine/Propofol and Methohexital Anesthesia for ECT

Medical University of Vienna

ECTDepression
Completed·Phase 1·psilocybin

Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain

Emory University

Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid Neoplasm
Completed·Phase 1·psilocybin

PsilOCD: A Pharmacological-Challenge Feasibility Study

Imperial College London

Obsessive-Compulsive Disorder
Completed·Phase 1·LSD

Effects of SERT Inhibition on the Subjective Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Early Phase 1·ketamine

Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer

Cedars-Sinai Medical Center

AnxietyPancreatic Cancer
Completed·Phase 2·psilocybin

Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study

COMPASS Pathways

Anorexia Nervosa
Completed·Phase 3·ketamine

Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents

University of Texas Southwestern Medical Center

Suicide, AttemptedSuicide and DepressionSuicide Threat
Completed·Phase 1·MDMA

Acute Effects of R- and S-MDMA in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·ketamine

Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001

Cessatech A/S

Pain
Completed·Phase 2·ketamine

The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy

Madeline Fields

Drug Resistant EpilepsyMedically Refractory EpilepsyRefractory Epilepsy
Completed·Phase 2·LSD

A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety Symptoms

Definium Therapeutics US, Inc.

Anxiety Generalized
Completed·Phase 2·ketamine

Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression

Joshua Rosenblat

Bipolar DisorderBipolar DepressionBipolar I Disorder+1 more
Completed·N/A·MDMA

Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD

Albany Research Institute, Inc.

Post Traumatic Stress Disorder
Completed·Phase 3·ketamine

Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient

Assistance Publique Hopitaux De Marseille

Traumatic Injury
Completed·Phase 1·psilocybin

A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive Disorder

Cybin IRL Limited

Major Depressive Disorder
Completed·Phase 1·MDMA

Food Effects on Bioavailability of MDMA in Healthy Volunteers

Resilient Pharmaceuticals

Pharmacokinetics
Completed·Phase 4·ketamine

Anhedonia, Development, and Emotions: Phenotyping and Therapeutics

Erika Forbes

DepressionAnhedonia
Completed·Phase 2·ketamine

Ketamine for Treatment-Resistant Bipolar Disorder

Joshua Rosenblat

Bipolar DisorderBipolar DepressionBipolar I Disorder+1 more
Completed·Phase 1·psilocybin

Effects of Psilocybin in Post-Treatment Lyme Disease

Johns Hopkins University

Post-Treatment Lyme DiseaseChronic Lyme DiseaseLyme Disease, Chronic
Completed·Phase 1·psilocybin

An Evaluation of Psilocybin's Effect on Cardiac Repolarization and the Effect of Food on Psilocybin's Pharmacokinetics

Usona Institute

QTc IntervalPharmacokinetics
Completed·Phase 2·psilocybin

The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

COMPASS Pathways

Post Traumatic Stress Disorder
Completed·Phase 1·ketamine

Investigation of Intranasal Ketamine Related Changes in Attentional Brain Networks With Functional and Structural MRI

Rupert Lanzenberger

Ketamine Treatment
Completed·Early Phase 1·ketamine

Effects of Ketamine on ERP/EEG Measures in Healthy Volunteers

ERP Biomarker Qualification Consortium

Healthy
Completed·Early Phase 1·MDMA

Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function

University of Chicago

Stimulant UseMDMA ('Ecstasy')Social Behavior+1 more
Completed·Phase 2·ketamine

Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic Targets

University of Texas Southwestern Medical Center

Major Depressive DisorderHealthy Controls
Completed·N/A·ketamine

Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression

Centre for Addiction and Mental Health

Bipolar Disorder (BD)Suicidality
Completed·Phase 1·LSD

Effects of LSD on Neuroplasticity in Healthy Subjects

University of Fribourg

Healthy
Completed·Phase 3·ketamine

Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial

Washington University School of Medicine

Postoperative Depression
Completed·Phase 2·MDMA

Social Anxiety MDMA-Assisted Therapy Investigation

Jason B Luoma

Social Anxiety Disorder
Completed·N/A·ketamine

Tolerance and Potential Synergistic Effect of the Combination of Intranasal Esketamine and Non-selective MAOI

University Hospital, Strasbourg, France

Depression Anxiety Disorder
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.