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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 193–240 of 1553 trials
Completed·Phase 4·ketamine

Randomized Trial of Sedative Choice for Intubation

Vanderbilt University Medical Center

Acute Respiratory Failure
Completed·N/A·ketamine

Chart Review of Patients Undergoing Ketamine Treatments for Depression

Sunnybrook Health Sciences Centre

Depression - Major Depressive Disorder
Completed·N/A·ketamine

Effect of Ketamine on BIS Values

University of Padova

Anesthesia Brain MonitoringKetamine
Completed·Phase 2·psilocybin

The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation

Sheppard Pratt Health System

Treatment Resistant DepressionSuicidal Ideation
Completed·Phase 1·LSD

LSD Base and LSD Tartrate Bioequivalence and Bioavailability in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·psilocybin

Evaluation of Psilocybin (TRP-8802) in the Treatment of Binge Eating Disorder

TRYP Therapeutics

Binge Eating Disorder
Completed·Phase 2·psilocybin

Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice Care

Yvan Beaussant, MD, MSci

HospicePsilocybinDemoralization+5 more
Completed·Phase 3·psilocybin

Frontline Clinician Psilocybin Study

University of Washington

Burnout, CaregiverBurnout, ProfessionalCOVID-19+3 more
Completed·Phase 1·ketamine

Ketamine + Mindfulness for Depression

Rebecca Price

Depression, Unipolar
Completed·Phase 2·ketamine

A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD

Perception Neuroscience

Treatment Resistant Depression
Completed·N/A·ketamine

Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest

University of Milano Bicocca

Status EpilepticusCardiac Arrest
Completed·Phase 2·LSD

Safety and Efficacy of Low Dose MM120 for ADHD Proof of Concept Trial

Definium Therapeutics US, Inc.

ADHDAttention Deficit Disorder
Completed·Phase 1·MDMA

Effects of MDMA-like Substances in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·ketamine

Ketamine for the Treatment of Depression in Parkinson's Disease

Yale University

Parkinson's DiseaseDepression
Completed·Phase 2·psilocybin

Psilocybin for Treatment-Resistant Depression

Brain and Cognition Discovery Foundation

Treatment Resistant Depression
Completed·N/A·ibogaine

Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure

Stanford University

Blast or Combat ExposureHead Injury Trauma
Completed·Phase 2·ketamine

Effectiveness of Ketamine Administered by Mesotherapy in Complex Regional Pain Syndrome Type 1 (CRPS1)

Hospices Civils de Lyon

Neuropathic PainComplex Regional Pain Syndrome Type 1
Completed·N/A·MDMA

Stanford Regulating Circuits of the Brain Study - MDMA

Stanford University

Healthy
Completed·N/A·ketamine

Intranasal Ketamine in Ultra-REsistant Depression (SURE-ECT Non Responders)

Centre for Addiction and Mental Health

Depression
Completed·N/A·ketamine

Synaptic Imaging and Network Activity in Treatment Resistant Depression

King's College London

Depressive DisorderDepressive Disorder, MajorDepressive Disorder, Treatment-Resistant+5 more
Completed·Phase 1·psilocybin

Identification of a Safe and Non-Psychedelic Dose of Psilocybin

Diamond Therapeutics Inc.

Healthy Controls
Completed·Phase 4·ketamine

Comparison of Nebulized Ketamine to Intravenous Sub-Dissociative Dose Ketamine for Pain

Antonios Likourezos

Pain
Completed·Phase 2·MDMA

A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD)

Remedy

Post Traumatic Stress Disorder
Completed·Early Phase 1·psilocybin

Study of Psilocybin Enhanced Group Psychotherapy in Patients With Cancer

University of Utah

Cancer
Completed·Phase 4·ketamine

Low Dose Ketamine for Blunt Thoracic Trauma

North Memorial Health Care

Blunt Injury of ThoraxMultiple Rib Fractures, Involving Three Ribs
Completed·Early Phase 1·ketamine

Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine

King's College London

Depressive Disorder, Treatment-Resistant
Completed·Phase 1·DMT

Single Ascending Dose Study With 5-MeO-DMT in Healthy Subjects

Beckley Psytech Limited

Pharmacokinetics in Healthy Adults
Completed·Phase 1·ketamine

Study of SAGE-904 Using a Ketamine Challenge to Evaluate Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy Participants

Supernus Pharmaceuticals, Inc.

Healthy Volunteer
Completed·N/A·ayahuasca

Entheogen Resurgence

Vireo Health

Psychedelic Experiences
Completed·Phase 1·ketamine

Repeated Neurocognitive Measurements in Depressed Patients

Rebecca Price

Depression, Unipolar
Completed·Phase 4·ketamine

Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)

University Hospital, Clermont-Ferrand

Refractory Chronic Cluster Headache
Completed·Phase 3·ketamine

Ketamine As an Adjunctive Therapy for Major Depression (2)

University of Dublin, Trinity College

Major Depressive EpisodeUnipolar DepressionBipolar Depression
Completed·N/A·ketamine

Simultaneous Application of Ketamine and Lidocaine During an Ambulatory Infusion Therapy as a Treatment Option in Refractory Chronic Pain Conditions

University Hospital, Basel, Switzerland

Chronic Pain
Completed·Phase 2·psilocybin

Psilocybin Therapy for Depression and Anxiety in Parkinson's Disease

Joshua Woolley, MD, PhD

Parkinson DiseaseDepressionAnxiety
Completed·Phase 1·mescaline

Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·psilocybin

Repeat Dosing of Psilocybin in Migraine Headache

Yale University

Migraine Headache
Completed·Early Phase 1·MDMA

Drug Effects on Interpersonal Interaction

University of Chicago

Interaction, Social
Completed·Phase 2·MDMA

MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD

VA Loma Linda Health Care System

Post Traumatic Stress DisorderCombat Stress Disorders
Completed·Phase 1·ketamine

A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

National Institute of Nursing Research (NINR)

Fatigue
Completed·Phase 3·DMT

Open Label Randomized Multicenter to Assess Efficacy & Tolerability of Ofatumumab 20mg vs. First Line DMT in RMS

Novartis Pharmaceuticals

Multiple Sclerosis
Completed·Phase 2·ketamine

A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)

Melt Pharmaceuticals

Cataract
Completed·Phase 1·DMT

Pharmacokinetics of GH001 in Healthy Volunteers

GH Research Ireland Limited

Healthy Volunteers
Completed·Phase 2·psilocybin

Psilocybin in Depression Resistant to Standard Treatments

King's College London

Treatment Resistant Depression
Completed·Phase 1·DMT

Effects of Dimethyltryptamine in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·ketamine

The Effect of Opioid-Free Anesthesia in TMJ Surgery

Massachusetts General Hospital

Temporomandibular Joint Disorders
Completed·Phase 2·psilocybin

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression

Central Institute of Mental Health, Mannheim

Treatment-resistant Depression
Completed·N/A·ketamine

Effects of S-ketamine on Perioperative Opioid Consumption

Erasme University Hospital

Pain ManagementPostoperative PainOpioid Consumption, Postoperative+1 more
Completed·Phase 2·ketamine

Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD

Icahn School of Medicine at Mount Sinai

PTSD
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.