347 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 1–48 of 1553 trials
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD
Unity Health Toronto
Post Traumatic Stress DisorderPTSDChronic PTSD
Active, Not Recruiting·Phase 2·psilocybin
Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies
University of Washington
AnxietyDepressionHematopoietic and Lymphatic System Neoplasm+1 more
Active, Not Recruiting·Phase 1·psilocybin
Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD
Scottsdale Research Institute
PTSD
Active, Not Recruiting·Phase 2·ketamine
A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression
Daniel Lindqvist
Major Depressive Disorder (MDD)
Active, Not Recruiting·Phase 2·psilocybin
Wellcome Leap Psilocybin for OUD
Anna Rose Childress, Ph.D.
Opioid Use Disorder
Active, Not Recruiting·Phase 2·psilocybin
PsiloStudy: Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)
Nathan Brashares Sackett
Alcohol Use Disorder (AUD)PTSD
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study
McMaster University
Cannabis Use Disorder, ModerateCannabis Use Disorder, Severe
Active, Not Recruiting·Early Phase 1·ketamine
Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology
CAMC Health System
SedationInterventional RadiologyBiopsy+1 more
Active, Not Recruiting·N/A·psilocybin
Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism
Healing Advocacy Fund
Alcohol Use Disorder
Active, Not Recruiting·Phase 3·LSD
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)
Definium Therapeutics US, Inc.
Generalized Anxiety Disorder
Active, Not Recruiting·Phase 4·ketamine
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
Stanford University
Chronic PainDepression
Active, Not Recruiting·Phase 1·ketamine
Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural Connectome
Massachusetts General Hospital
DepressionSuicide
Active, Not Recruiting·N/A·ketamine
Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and Anhedonia
University Hospital, Montpellier
Depression - Major Depressive DisorderDepression DisorderSuicide
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin-assisted Treatment for Cannabis Use Disorder
Johns Hopkins University
Cannabis Use Disorder
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin for Treatment-Resistant Depression in Autism
Centre for Addiction and Mental Health
Treatment Resistant DepressionAutism Spectrum Disorder
Active, Not Recruiting·Phase 2·ketamine
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Icahn School of Medicine at Mount Sinai
DepressionMild Cognitive Impairment
Active, Not Recruiting·Phase 3·MDMA
MDMA-assisted Massed Prolonged Exposure for PTSD
Healing Breakthrough
Post-Traumatic Stress Disorder
Active, Not Recruiting·N/A·DMT
A Non-interventional Study Evaluating Clinical Utility and Implications on Improved Patient Management of Serum Neurofilament as a Prognostic Marker for Disease Activity in Patients With Relapsing Multiple Sclerosis
Novartis Pharmaceuticals
Multiple Sclerosis
Active, Not Recruiting·Phase 1·psilocybin
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression
University Health Network, Toronto
Bipolar Depression
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin in Cancer Pain Study
Yvan Beaussant, MD, MSci
Opioid-Related DisordersPain ManagementPain Management and Care+2 more
Active, Not Recruiting·Early Phase 1·MDMA
MDMA-Assisted Therapy for Pathological Narcissism
University of Washington
Narcissism
Active, Not Recruiting·Phase 1·psilocybin
A Study of Psilocybin for PTSD
Johns Hopkins University
Post Traumatic Stress Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer
University Health Network, Toronto
Advanced CancerStage IV Solid Tumor CancerStage IV Sarcoma of Bone+3 more
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin-Assisted Therapy in Treatment-Resistant Depression
University of North Carolina, Chapel Hill
Refractory DepressionTreatment Resistant Depression
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of Psilocybin
University Health Network, Toronto
Major Depressive DisorderDepressionTreatment-Resistant Depression+1 more
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
Peggy C Nopoulos
Alcohol Use Disorder
Active, Not Recruiting·Phase 4·ketamine
Neural Circuit Effects of Ketamine in Depression
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Active, Not Recruiting·Phase 3·ketamine
Predictors of Intravenous Ketamine Response in TRD
Abraham Nunes
Treatment Resistant DepressionMajor Depressive DisorderBipolar Disorder
Active, Not Recruiting·Phase 2·psilocybin
Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
TRYP Therapeutics
Irritable Bowel Syndrome
Active, Not Recruiting·Phase 1·psilocybin
PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL)
Ottawa Hospital Research Institute
Depression, AnxietyDistress, Emotional
Active, Not Recruiting·Phase 2·ketamine
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial
University Health Network, Toronto
Major Depressive DisorderSuicideTreatment Resistant Depression
Active, Not Recruiting·Early Phase 1·LSD
LSD Occupancy of the Serotonin 2A Receptor in the Human Brain
Copenhagen University Hospital, Rigshospitalet
Basic Science
Active, Not Recruiting·Phase 2·psilocybin
Two Doses of Psilocybin for the Treatment of MDD in Adults With Cancer
Sunstone Medical
CancerMajor Depressive Disorder
Active, Not Recruiting·Phase 2·ketamine
Enhancing Week-long Psychological Treatment for PTSD With Ketamine
Yale University
Posttraumatic Stress Disorder
Active, Not Recruiting·Phase 1·psilocybin
Neural and Physiological Correlates of Psychedelic Sub-states
Robin Carhart-Harris, PhD, MA
Psychedelic ExperiencesNeuroimagingHealthy Volunteers
Active, Not Recruiting·Phase 1·psilocybin
Effects of Repeated Psilocybin Dosing in OCD
Yale University
Obsessive-Compulsive Disorder
Active, Not Recruiting·Phase 2·ketamine
Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial
New York State Psychiatric Institute
Post-acute Sequelae of COVID-19Depressive SymptomsCognitive Dysfunction
Active, Not Recruiting·Phase 3·psilocybin
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
COMPASS Pathways
Treatment Resistant Depression
Active, Not Recruiting·Phase 2·psilocybin
A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder
COMPASS Pathways
Major Depressive Disorder
Active, Not Recruiting·Phase 1·DMT
Single and Repeat Doses of DMT in Healthy Subjects
Algernon Pharmaceuticals
Stroke
Active, Not Recruiting·Phase 2·ketamine
Ketamine for Multiple Sclerosis Fatigue
Johns Hopkins University
Multiple Sclerosis Fatigue
Active, Not Recruiting·Early Phase 1·psilocybin
Effects of Psilocybin in Obsessive Compulsive Disorder
Johns Hopkins University
Obsessive-Compulsive Disorder
Active, Not Recruiting·Phase 1·psilocybin
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
Eleusis Therapeutics
Healthy VolunteersMajor Depressive DisorderDepression
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin-assisted Therapy for Phantom Limb Pain
University of California, San Diego
Phantom Limb Pain
Active, Not Recruiting·N/A·ibogaine
Trifecta Research Study
Axial Therapeutic Research
PTSD - Post Traumatic Stress DisorderCognitive DysfunctionBrain Injury+2 more
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder
Portland VA Research Foundation, Inc
Amphetamine-Related Disorders
Active, Not Recruiting·Phase 4·ketamine
Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study
Ohio State University
Major Depressive Disorder
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Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.