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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 145192 of 1766 trials
Completed·Phase 1·psilocybin

Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·Other

Anesthesia Depth During Opioid Free Anesthesia

Region Halland

Opioid-free AnesthesiaAnesthesia Depth Monitoring
Completed·Early Phase 1·MDMA

Prosocial Effects of MDMA

University of Chicago

MDMA ('Ecstasy')Social Interaction
Completed·Phase 2·psilocybin

Microdosing Psychedelics to Improve Mood

Rotem Petranker

Major Depressive Disorder
Completed·N/A·DMT

A Study to Describe the Switching From a First- or Second-line Disease Modifying Therapy (DMT) to Ozanimod in Participants With Relapsing Remitting Multiple Sclerosis (RRMS)

Bristol-Myers Squibb

Multiple Sclerosis, Relapsing-Remitting
Completed·N/A·ketamine

Brain Network Dynamics of Depression During Esketamine Treatment

University of North Carolina, Chapel Hill

Depressive Disorder, Major
Completed·Phase 2·psilocybin

Does Psilocybin Require Psychedelic Effects to Treat Depression?

Centre for Addiction and Mental Health

Treatment-resistant Depression
Completed·Phase 1·psilocybin

Psilocybin-Assisted Therapy for the Treatment of Cancer-Related Anxiety in Patients With Metastatic Cancer

University of Washington

Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid Neoplasm
Completed·Phase 1·psilocybin

Psilocybin-assisted CBT for Depression

University of California, Los Angeles

Major Depressive Disorder
Completed·N/A·ketamine

The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery

Tiva Group

Pharmacological ActionPost Operative PainOpioid Use+2 more
Completed·Phase 2·DMT

A Trial of GH001 in Patients With Treatment-resistant Depression

GH Research Ireland Limited

Treatment-resistant Depression
Completed·N/A·ketamine

Lidocaine and Ketamine Levels in Plasma After Simultaneous Lidocaine/Ketamine Infusions

University Hospital, Basel, Switzerland

Chronic Pain
Completed·Phase 4·Other

Opioid-free Analgesia in Intensive Care Unit

Centre Hospitalier Universitaire de Nīmes

Intubation
Completed·Phase 1·DMT

Dose-finding Study for the Combination of DMT and Harmine in Healthy Subjects

Reconnect Labs

Healthy
Completed·Early Phase 1·ketamine

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Medical University of South Carolina

Tobacco UseSmoking CessationNicotine Dependence
Completed·N/A·ketamine

Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression

Medical University of Gdansk

Treatment-Resistant DepressionMajor Depressive Disorder
Completed·Phase 1·psilocybin

Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers

University of Nebraska

Pancreas CancerBiliary Tract CancerPsychological Distress+1 more
Completed·N/A·ketamine

Effect of Ketamine Infusion on BIS Values

University of Padova

Anesthesia Brain MonitoringKetamine
Completed·N/A·ketamine

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Beth Israel Deaconess Medical Center

Postoperative DeliriumHemodynamic InstabilityPain+1 more
Completed·Early Phase 1·ayahuasca

Mindfulness and Psychedelics

Milan Scheidegger

Healthy Participants
Completed·N/A·DMT

Real-World Persistence and Adherence of Ofatumumab Compared to Self-Injectable and Oral DMTs in Patients With Multiple Sclerosis

Novartis

Multiple Sclerosis
Completed·Early Phase 1·ketamine

The Effects of Sedatives on Tobacco Use Disorder Version 2

Wake Forest University Health Sciences

Tobacco Smoking
Completed·Phase 3·psilocybin

Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD

COMPASS Pathways

Treatment Resistant Depression
Completed·N/A·DMT

The 'Wearing Off' Effect of DMT

Novartis Pharmaceuticals

Multiple Sclerosis
Completed·Phase 1·Other

IM and IV SPL026 Drug Product in Healthy Participants

Small Pharma Ltd

Major Depressive Disorder
Completed·Phase 1·psilocybin

PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout

University of Utah

DepressionBurnout, Professional
Completed·Phase 1·DMT

Pharmacokinetics, Safety, and Tolerability of Intramuscular 5-MeO-DMT in Healthy Volunteers

Usona Institute

PharmacokineticsSafetyTolerability
Completed·Phase 1·DMT

Safety and Pharmacokinetics of GH002 in Healthy Volunteers

GH Research Ireland Limited

Healthy Volunteers
Completed·Phase 1·DMT

SPL026 With or Without SSRIs in Participants With MDD

Small Pharma Ltd

Major Depressive Disorder
Completed·N/A·psilocybin

Psilocybin in Adults With and Without Autism Spectrum Disorder

King's College London

Autism Spectrum Disorder
Completed·Phase 4·ketamine

Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects

Summa Health System

Pain, AcuteDissociation
Completed·Phase 4·ketamine

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

Theresa Jacob, PhD, MPH

Treatment Resistant DepressionMajor Depressive DisorderAnalgesia+10 more
Completed·N/A·Other

Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia

University Hospital, Basel, Switzerland

Analgesia
Completed·Phase 1·DMT

Acute Dose-dependent Effects of DMT in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·psilocybin

Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain

Emory University

Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid Neoplasm
Completed·Phase 1·psilocybin

PsilOCD: A Pharmacological-Challenge Feasibility Study

Imperial College London

Obsessive-Compulsive Disorder
Completed·Phase 1·LSD

Effects of SERT Inhibition on the Subjective Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Early Phase 1·ketamine

Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer

Cedars-Sinai Medical Center

AnxietyPancreatic Cancer
Completed·Phase 2·psilocybin

Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study

COMPASS Pathways

Anorexia Nervosa
Completed·Phase 1·psilocybin

Psilocybin-assisted Therapy for Phantom Limb Pain

University of California, San Diego

Phantom Limb Pain
Completed·Phase 3·ketamine

Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents

University of Texas Southwestern Medical Center

Suicide, AttemptedSuicide and DepressionSuicide Threat
Completed·Phase 1·MDMA

Acute Effects of R- and S-MDMA in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·ketamine

Efficacy and Pharmacokinetic-Pharmacodynamic Relationship of Intranasally Administered Sufentanil, Ketamine, and CT001

Cessatech A/S

Pain
Completed·Phase 2·ketamine

The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy

Madeline Fields

Drug Resistant EpilepsyMedically Refractory EpilepsyRefractory Epilepsy
Completed·Phase 2·LSD

A Dose-Finding Study of MM120 (LSD D-Tartrate) for the Treatment of Anxiety Symptoms

Definium Therapeutics US, Inc.

Anxiety Generalized
Completed·Phase 2·ketamine

Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression

Joshua Rosenblat

Bipolar DisorderBipolar DepressionBipolar I Disorder+1 more
Completed·N/A·MDMA

Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD

Albany Research Institute, Inc.

Post Traumatic Stress Disorder
Completed·Phase 3·ketamine

Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient

Assistance Publique Hopitaux De Marseille

Traumatic Injury
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.