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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 11531200 of 1750 trials
Recruiting·Early Phase 1·psilocybin

Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis

Johns Hopkins University

Amyotrophic Lateral Sclerosis
Recruiting·Phase 2·ketamine

Understanding and Treating Suicidal Ideation With Ketamine

The Royal's Institute of Mental Health Research

Suicidal IdeationMajor Depressive Disorder (MDD)
Recruiting·Early Phase 1·psilocybin

Psilocybin for Methamphetamine Addiction

Kevin Murnane

Methamphetamine Use Disorder
Recruiting·Phase 1·psilocybin

Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants

University Hospital, Basel, Switzerland

Healthy
Recruiting·Phase 2·psilocybin

Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

Centre for Addiction and Mental Health

Treatment Resistant DepressionChronic Pain
Recruiting·N/A·Other

Screening for Anti-amyloid Treatment Eligibility Using Digital Cognition and Blood-based Biomarkers

MoCA Clinic and Institute

Mild Cognitive ImpairmentAlzheimer DiseaseDementia
Recruiting·Phase 1·DMT

Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans

Deepak C. D'Souza

Major Depression DisorderDepression
Recruiting·Phase 2·psilocybin

Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN

Unity Health Toronto

Chronic Neuropathic PainPain Management
Recruiting·Phase 2·MDMA

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Stephen Robert Marder

Post Traumatic Stress Disorder
Recruiting·Phase 1·psilocybin

Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs

University College, London

Healthy
Recruiting·Phase 2·psilocybin

Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study

McMaster University

Cannabis Use Disorder, ModerateCannabis Use Disorder, Severe
Recruiting·Phase 3·ketamine

Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine

Assistance Publique - Hôpitaux de Paris

Limb Injury
Recruiting·Phase 2·psilocybin

Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder

Icahn School of Medicine at Mount Sinai

Major Depressive Disorder
Recruiting·Phase 2·ketamine

Intravenous Ketamine for Treatment-Resistant Depression

Mayo Clinic

Depressive Disorder, Treatment-ResistantTreatment Resistant Depression (TRD)
Recruiting·Phase 2·MDMA

MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder

Patricia Suppes

PTSD
Recruiting·Phase 1·psilocybin

Investigation of Psychedelic Effects in Psychoactive Substances

Johns Hopkins University

Psychedelic Effects in Healthy Volunteers
Recruiting·Phase 2·Other

Non-steroidal Anti-inflammatory Drugs in Pleurodesis

Centre Hospitalier Universitaire, Amiens

Non-steroidal Anti-inflammatory DrugsPleurodesisPneumothorax+1 more
Recruiting·Phase 2·psilocybin

State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma

Baylor College of Medicine

PTSD
Recruiting·Phase 1·psilocybin

The ENHANCE Study: taVNS and Psilocybin

University of Wisconsin, Madison

HealthyPsychedelic ExperiencesVagus Nerve Stimulation
Recruiting·N/A·MDMA

Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls

University Hospital, Basel, Switzerland

Central Diabetes Insipidus
Recruiting·Phase 3·ketamine

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

Yale University

Depression
Recruiting·Phase 1·ketamine

Ketamine for Combined Depression and Alcohol Use Disorder

University Hospital of North Norway

DepressionAlcohol Use Disorder
Recruiting·Phase 2·psilocybin

Pragmatic Trial of Psilocybin Therapy in Palliative Care

Charles S. Grob, M.D.

Demoralization
Recruiting·Phase 1·psilocybin

Psilocybin-Assisted Therapy for Physician Well-Being and Burnout

University of California, San Diego

BurnoutBurnout, Healthcare Workers
Recruiting·Phase 2·ketamine

Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression

Icahn School of Medicine at Mount Sinai

Major Depressive Disorder
Recruiting·Phase 2·psilocybin

Psilocybin rTMS for Treatment Resistant Depression

University of Texas at Austin

Treatment Resistant DepressionMDDMajor Depressive Disorder+2 more
Recruiting·Phase 3·psilocybin

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

Cybin IRL Limited

Major Depressive Disorder
Recruiting·N/A·Other

Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study

Unity Health Toronto

Major Depressive Disorder (MDD)Major Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Recruiting·Phase 2·ketamine

Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest

Christian Hassager

Out-of-hospital Cardiac Arrest (OHCA)
Recruiting·Phase 1·psilocybin

Safety for Home Administration of Microdose Psilocybin Use

Johns Hopkins University

Psychedelic Experiences
Recruiting·Phase 4·ketamine

Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine

Insel Gruppe AG, University Hospital Bern

Endometriosis
Recruiting·N/A·Other

Modulation of the Inflammatory Response in Bariatric Surgery

Hospital HM Nou Delfos

ObesityBariatric Surgery CandidateInflammation+3 more
Recruiting·Phase 1·psilocybin

Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence

University of Colorado, Denver

Breast CancerOvarian Cancer
Recruiting·Phase 2·psilocybin

Study of Psilocybin for Anorexia in Young Adults

Marissa Raymond-Flesch, MD, MPH

Anorexia Nervosa
Recruiting·Phase 2·MDMA

MDMA-Assisted CBCT for PTSD vs CBCT RCT

Remedy

Post Traumatic Stress Disorder
Recruiting·N/A·ketamine

Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life

Albany Research Institute, Inc.

Depression
Recruiting·Phase 1·psilocybin

Psilocybin-assisted Treatment for Cannabis Use Disorder

Johns Hopkins University

Cannabis Use Disorder
Recruiting·Phase 2·ketamine

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

National Institute of Mental Health (NIMH)

SuicideDepressive Disorder, Treatment-ResistantKetamine+10 more
Recruiting·Phase 1·psilocybin

Psilocybin for Treatment-Resistant Depression in Autism

Centre for Addiction and Mental Health

Treatment Resistant DepressionAutism Spectrum Disorder
Recruiting·Phase 3·MDMA

MDMA-assisted Massed Prolonged Exposure for PTSD

Healing Breakthrough

Post-Traumatic Stress Disorder
Recruiting·Phase 2·psilocybin

Investigating the Interaction of Psilocybin and Context of Its Administration in Healthy Volunteers

Robin Carhart-Harris, PhD, MA

Healthy Participants With Lower-than-average Mental Well-being
Recruiting·Phase 3·ketamine

Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients

Assistance Publique - Hôpitaux de Paris

Major Depressive Episode
Recruiting·Phase 1·psilocybin

Open-Label Psilocybin Study in Transdiagnostic Population

Yale University

TransdiagnosticDepression - Major Depressive DisorderAnxiety+5 more
Recruiting·Phase 3·ketamine

Nebulized Ketamine for the Treatment of Major Depressive Disorder

Theresa Jacob, PhD, MPH

Severe DepressionModerate DepressionKetamine+14 more
Recruiting·Phase 1·psilocybin

Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar Depression

University Health Network, Toronto

Bipolar Depression
Recruiting·N/A·Other

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

Oregon Health and Science University

Otolaryngological DiseaseObstructive Sleep Apnea
Recruiting·Phase 4·ketamine

The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD

Margaux M. Salas, PhD

Neuropathic PainPTSD
Recruiting·N/A·Other

At-Home tDCS as Maintenance Therapy

Technical University of Munich

MDDSevere DepressionMajor Depressive Episode
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.