347 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 49–96 of 347 trials
Not Yet Recruiting·Phase 2·ketamine
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
National Center for Complementary and Integrative Health (NCCIH)
Healthy Volunteers
Not Yet Recruiting·Phase 2·psilocybin
NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy
M.D. Anderson Cancer Center
PsilocybinNeuropathy
Not Yet Recruiting·Phase 4·ketamine
Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section
Assiut University
ShiveringPost-Spinal ShiveringHypothermia+1 more
Not Yet Recruiting·Phase 4·ketamine
Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery
Assiut University
Postoperative VomitingPostoperative Nausea and VomitingStrabismus
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
Nicky Mehtani, MD, MPH
Methamphetamine Use DisorderHuman Immunodeficiency Virus (HIV)
Not Yet Recruiting·Phase 2·MDMA
MDMA-AT for PTSD in Young Adults With Childhood Trauma
Jenna M. Traynor
Posttraumatic Stress Disorder (PTSD)
Not Yet Recruiting·Phase 2·psilocybin
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') Trial
University of Calgary
Advanced CancerDemoralizationExistential Distress+1 more
Not Yet Recruiting·Phase 2·ketamine
Adjunctive Oral KET-AD Capsules in Treatment Resistant Bipolar Depression
Neurocentrx Pharma Pty Ltd
Treatment Resistant Bipolar Depression
Not Yet Recruiting·N/A·ketamine
Esketamine Combined With Transcutaneous Electrical Acupoint Stimulation on Postoperative Recovery Quality After Elective Cesarean Section
Anhui Provincial Hospital
Cesarean Section (MeSH: D002585)Postoperative Pain After Cesarean SectionEnhanced Recovery After Surgery
Not Yet Recruiting·Phase 3·ketamine
KetAmine and Recovery After Mechanical VentilAtion ( KARMA )
Assistance Publique - Hôpitaux de Paris
Critical Illness
Not Yet Recruiting·Phase 1·ketamine
Oral and Sublingual Ketamine
Western University, Canada
Major Depression Severe
Not Yet Recruiting·N/A·ketamine
Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit
Ain Shams University
CPAP VentilationSedationHemodynamics Instability
Not Yet Recruiting·Phase 4·ketamine
Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts
New York State Psychiatric Institute
Major Depressive Disorder (MDD)
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence
University of Calgary
Post Traumatic Stress Disorder PTSDIntimate Partner Violence (IPV)
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin Microdosing on Cognition, Mood and Quality of Life
Yale University
Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI
Not Yet Recruiting·Phase 4·ketamine
Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis
Assistance Publique - Hôpitaux de Paris
Sickle Cell DiseaseVaso-occlusive Crisis
Not Yet Recruiting·Phase 2·MDMA
Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress Disorder
U.S. Army Medical Research and Development Command
PTSDPost Traumatic Stress Disorder PTSDPost Traumatic Stress Disorder
Not Yet Recruiting·Phase 2·MDMA
MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers and First Responders
Nautilus Sanctuary
Post-Traumatic Stress DisorderAdjustment Disorders
Not Yet Recruiting·N/A·ketamine
Outcomes Registry After Ketamine Infusions for Chronic Pain: A Longitudinal Evaluation
Stanford University
Chronic PainKetamine
Not Yet Recruiting·Phase 4·ketamine
Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy
Assiut University
NephrolithiasisPostoperative PainQuality of Recovery
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled Trial
University Health Network, Toronto
Advanced CancerStage IV Solid Tumor CancerStage IV Sarcoma of Bone+3 more
Not Yet Recruiting·Phase 1·psilocybin
Psilocybin for Treatment of OCD-2
Francisco A Moreno
Obsessive - Compulsive Disorder
Not Yet Recruiting·Phase 1·psilocybin
The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.
Gabriella Gobbi
Healthy ParticipantsPlacebo - ControlPsilocybin
Not Yet Recruiting·Phase 1·DMT
Neural Effects of Intravenous N,N-dimethyltryptamine (DMT)
Jon Dean
Healthy Participants Study
Not Yet Recruiting·Phase 1·psilocybin
The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function
Manoj Doss
Healthy
Not Yet Recruiting·Phase 2·ketamine
Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression
The Royal's Institute of Mental Health Research
Treatment Resistant DepressionMajor Depressive Disorder (MDD)
Not Yet Recruiting·N/A·ketamine
Ketamine Treatment for Treatment-Resistant Depression - the Role of Framing
Valdemar Landgren
Treatment Resistant Depression (TRD)
Not Yet Recruiting·Phase 1·psilocybin
The Effects of Psilocybin on Social Connectedness
Yale University
LonelinessGrief
Not Yet Recruiting·Phase 4·ketamine
Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy
Assiut University
Postoperative Pain
Not Yet Recruiting·Phase 4·ketamine
Low Dose Bolus Ketamine For Use In Sickle Cell Pain Crisis
University of Mississippi Medical Center
Vaso-Occlusive Pain Episode in Sickle Cell DiseaseSickle Cell Disease (SCD)
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)
NYU Langone Health
IBS - Irritable Bowel Syndrome
Not Yet Recruiting·N/A·ketamine
Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot Study
Adriaan Dirk van der Wart
Post-Traumatic Stress Disorder
Not Yet Recruiting·N/A·ketamine
Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCP
Ren Da
Biliary Tract DiseasesProcedural Sedation and Analgesia
Not Yet Recruiting·Phase 2·psilocybin
Study of Psilocybin Under Anesthesia Controlled by EEG
Stanford University
Major Depression
Not Yet Recruiting·Phase 2·ketamine
Pilot Randomized Control Trial Comparing Oral Ketamine and Oral Oxycodone for Pain Control in Emergency Department Patients
Albany Medical College
Pain Management
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Therapy as a Treatment for Depression
Washington University School of Medicine
Depression
Not Yet Recruiting·N/A·MDMA
Circulating Oxytocin Changes in Response to MDMA vs. Placebo in Adult Patients With Autism Spectrum Disorder and Matched Healthy Controls
University Hospital, Basel, Switzerland
Autism Spectrum Disorder
Not Yet Recruiting·Phase 2·psilocybin
Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression
University of Washington
DepressionAnxiety
Not Yet Recruiting·N/A·LSD
Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)
Northern Jiangsu People's Hospital
Cirrhosis, LiverSplenectomy; StatusRenal Function Abnormal+1 more
Not Yet Recruiting·Phase 2·psilocybin
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy
Kyle Greenway
Treatment-Resistant Major Depressive Disorder
Not Yet Recruiting·N/A·ketamine
A 2×2 Factorial Randomized Controlled Trial for ERCP
Gang Chen
Biliary and Pancreatic DiseasesEndoscopic Retrograde Cholangiopancreatography (ERCP)
Not Yet Recruiting·N/A·ketamine
Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery
Tanta University
ObesityPostoperative PainBariatric Surgery
Not Yet Recruiting·Phase 1·MDMA
MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function
Resilient Pharmaceuticals
PharmacokineticsHepatic Impairment
Not Yet Recruiting·N/A·ketamine
Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery
Aga Khan University
Breast CancerPain, ChronicPost Surgical Pain
Not Yet Recruiting·Phase 1·ketamine
KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study
Helsinki University Central Hospital
Drug Drug Interaction
Not Yet Recruiting·Phase 2·ketamine
Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.
Fondation Lenval
TraumatologyWounds and InjuryFractures Bone+4 more
Not Yet Recruiting·N/A·ketamine
Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery
Nanjing First Hospital, Nanjing Medical University
Post Induction Hypotension
Not Yet Recruiting·N/A·ketamine
Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat
Sohag University
Postoperative Sore Throat
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View all conditions →How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.